Haploidentical donor versus double-unit cord blood transplantation in hematologic malignancies: comparative survival and graft-versus-host disease outcomes from a decade of real-world experience

Abstract Background Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for patients with hematologic malignancies, but the limited availability of HLA-matched sibling donors necessitates alternative graft sources. Haploidentical donors (HIDs) and double-unit umbilical cord blood (DUCB) are two widely used alternatives, yet direct comparisons of their clinical outcomes remain limited. Methods We conducted a retrospective single-center study of 97 patients with hematolo