Soortspecifieke snelheden van lipidenmetabolisme bepalen de tijdschaal van corticogenese via de dynamiek van eiwitacetylatie

Neurogenesis is a key event of neural development, by which neural stem/progenitor cells (NSPC) stop self-renewing and dividing, to convert to postmitotic neurons. The delicate balance between self-renewal and differentiation of NSPC is controlled by intrinsic and extrinsic cues, in particular transcription factors and morphogen signals (Bonnefont and Vanderhaeghen, 2021; Villalba et al., 2020)). On the other hand, recent evidence have uncovered the key influence of mechanisms once considered to