Spexin disrupts migrating myoelectric complex in the rat small intestine: The role of galanin-2 and muscarinic receptors

Abstract Spexin (SPX) is an endogenous peptide expressed throughout the gastrointestinal tract. Although its impact on postprandial intestinal motility has been examined, its effect during fasting remains unclear. This study aimed to investigate the direct effects of SPX on jejunal and ileal segments in vitro , its effects on fasting small intestinal motility in vivo , and to determine the roles of galanin-2, muscarinic, and 5-hydroxytryptamine-3 (5-HT₃) receptors in these actions. The contracti