Live birth following transfer of a euploid blastocyst derived from a 5PN zygote: a case report
Claudia Gomes·Aline Rodrigues Lorenzon·Bruna Lourenço·Dayane Guerino Reis·Beatriz Aiello·Izadora Reis·Leticia Tamashiro·Andrea Belo·Hanna Park·J.R. Alegretti·Dóris Spinosa Chéles·Mariana Nicolielo
Abstract Background Abnormal pronuclear formation, including five pronuclei (5PN), is generally considered indicative of abnormal fertilization (e.g., polyspermy or failure of polar body extrusion) and leads to routine embryo discard in many IVF programs. However, emerging evidence suggests that a minority of embryos with atypical pronuclear patterns may develop into a blastocyst and present diploid constitution after genetic testing, challenging the assumption that abnormal pronuclear morpholog