ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UNIVARIATE SPECTROPHOTOMETRIC METHODS FOR QUANTIFYING BINARY DRUG COMBINATION IN HYPERTENSIVE CARE

The objective of present research work was to develop a novel, precise, and accurate UV spectrophotometric method based on four approaches: Ratio Subtraction Coupled with Extended Ratio Subtraction Method (RS-ERSM), Ratio Subtraction Coupled with Constant Multiplication Method (RS-CM), Ratio subtraction coupled with Spectrum Subtraction (RS-SS) and the Absorption Factor method (AFM) for simultaneous estimation of Azelnidipine and Olmesartan medoxomil in fixed dose combination. The method was val