Network-based analysis reveals potential microRNA regulation of oncogenic pathways in SOX10-depleted uveal melanoma
Chunyan Luan·Xin Lai·Zhesi Zhang·Liang Zhang·Adrian Weich·Christopher Lischer·Carola Berking·Markus V. Heppt·Julio Vera·Anja Wessely
Abstract SOX10 is essential for melanocyte development and maintenance and plays a critical role in uveal melanoma (UM) initiation and progression. While SOX10’s transcriptional regulation of protein-coding genes is well characterized, its role on microRNA (miRNA) regulatory landscape in UM remains unexplored. Here, we employed network-based modeling to systematically characterize miRNA regulatory functions following SOX10 depletion in UM. First, we profiled mRNA and miRNA expression levels in S