A stochastic model of T cell expansion in micro-rod scaffolds and its continuum limit: importance of IL-2 loading and scaffold structure

Abstract T cells are immune cells that are known to be effective at fighting cancer. However, tumour-specific T cell counts are often insufficient to control cancer growths. Adoptive T cell therapy aims to leverage the cancer-killing functions of the immune system by activating and expanding highly effective T cells ex vivo before injecting them into a cancer patient. Recent experimental setups in which T cells are cultured within activating micro-rod scaffolds have achieved significantly improv