Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model
Krista Gunter·Natasha L. Tilston·Stephanie Pozuelos·Curtis Witt·Andrew T. Clarke·Dorcus C. A. Omoga·James Bowen·Lisa M. Rogers·David M. Aronoff·Andrew M. Lunel·Jay Vornhagen·Benjamin Brennan·Henry Giesel·Melanie McFarlane
Abstract Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy. Here, we establish an in vivo murine model of OROV vertical transmission using the ancestral (prototype) strain BeAn19991 in immunocompetent C57BL/6 J mice. We demonstrate that OROV robustly replicates in maternal tissues and efficientl