Gecoördineerde metabole herprogrammering en dendrietremodellering liggen aan de basis van succesvolle axonale regeneratie in het centrale zenuwstelsel

Brain injury and neurodegenerative disorders represent a growing socio-economic problem in our aging society, partly because the central nervous system (CNS) of mammals has a limited regenerative capacity. Most of the injured neurons die, and the few survivors fail to extend their axons beyond the damaged site. Despite many years of research, functional circuit regeneration is still not possible. Strikingly, up till now, dendrites and their contribution to neuronal regeneration have been largely