Epigenetic age acceleration measures and chemotoxicity in older adults with early breast cancer
Jingran Ji·Mina S. Sedrak·William Dale·Heeyoung Kim·Vani Katheria·C.M. Lee·Claire Smith·Na Sun·Yuan Chun Ding·Susan L. Neuhausen·Harvey J. Cohen·Alexandra Binder·Can-Lan Sun
Abstract Among older adults with early breast cancer, the risk of chemotoxicity can vary widely despite similar chronological age. Here, we evaluated whether epigenetic indicators of biological age can stratify the risk of chemotoxicity in this population. In a prospective study of 394 women age > 65 with stage I–III breast cancer treated with neo/adjuvant chemotherapy, we analyzed peripheral blood DNA methylation patterns to estimate epigenetic age acceleration (EAA) before chemotherapy. We