Oxidative stress is harmful for spermatic DNA, since high levels of reactive oxygen species lead to the formation of toxic adducts derived from DNA oxidation. This phenomenon is especially relevant under pathological conditions such as asthenozoospermia, necrozoospermia, oligozoospermia, or azoospermia. The nucleoside most susceptible to this damage is 2′-deoxyguanosine (2′-dG), which is oxidized to form 8-hydroxy-2′-deoxyguanosine (8-OHdG), one of the most widely studied biomarkers of oxidative