Antibiotic resistance in Aeromonas hydrophila associated with exposure to subtherapeutic levels of oxytetracycline

Introduction The aquatic environment is an ideal ecosystem for the development of antimicrobial resistance (AMR) as it can be impacted by many sources of antibiotic residues. Methods To better understand the mechanism for AMR associated with exposure to subtherapeutic concentrations of antibiotics, we monitored the genetic and transcriptional changes in Aeromonas hydrophila exposed to incremental doses of oxytetracycline (OTC), a commonly used antibiotic in aquaculture. Results Our results showe