Combined intervention program of serious virtual reality games focused on controllability and Stress Inoculation Training in patients with major depression

Introduction Major depressive disorder (MDD) is a debilitating mental health condition with a high global prevalence, characterized by profound psychological and neurobiological alterations. Although many patients respond effectively to pharmacological and psychotherapeutic interventions, the persistently high rate of treatment resistance underscores the urgent need for novel strategies that target stress regulation and promote neuroplasticity. The aim of this study was determining the effect of