Objective To evaluate the efficacy of postoperative screening for distress symptom cluster in patients undergoing surgery for pituitary adenoma (PA). Methods Prospectively collected data of 334 patients were reviewed. Patients undergoing screening were included in screening cohort. A 1:1 propensity-score matching was applied to select controls. Primary endpoint was Patient Reported Outcomes Measurement Information System (PROMIS) scores for pain interference, fatigue and sleep disturbance at 1 m