Cross-species characterisation of microglial morphology and proliferation during ageing
Laura M. Carr·Lyndsey E. Collins‐Praino·Shannon M. Stuckey·Sanam Mustafa·Renée J. Turner·Isabella M. Bilecki·Angus McNamara
By 2050, one-fifth of the world is expected to be over 60, and the prevalence of age-related neurological conditions is predicted to increase dramatically. Aged animals are currently underutilised in neurological research, leading to a gap in knowledge about the contribution of biological age to the pathophysiology of age-related neurological conditions. Additionally, it is unclear whether age-related changes differ across species used in preclinical models, and how these differences may compare