Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy
Krishan Kumar·Marcelo Calderón·Pegah Sanjarnia·María Soledad Orellano·Ana Beloqui·Lisa Ebo·Matias L. Picchio·Meltem Gurol
J-aggregates of cyanine dyes have emerged as powerful photothermal and imaging agents in the near-infrared (NIR) window due to their red-shifted absorption, narrow bandwidth, and strong excitonic coupling. However, their instability in biological environments often necessitates external carriers or stabilizers that compromise efficiency and biocompatibility. Here, we introduce deep eutectic solvents (DES) as a novel biocompatible medium to enhance the photothermal behavior of J-aggregates under