Programmable Chirality Transfer: Seeding-Directed Co-assembly of Functional Molecules with Amyloid Frameworks

We report a highly effective and universal strategy for linking small achiral functional molecules with amyloid fibrils, enabling efficient transfer of chirality from the chiral amyloid network to supramolecularly co-assembled entities. This seeding-and-co-assembly approach, based on incorporating functional molecules (e.g., dyes) during ongoing seed-directed amyloid formation, facilitates their templating by the amyloid framework while constraining fibril morphological diversity through suppres