Sex-Specific Differences in Post-Load Insulin Dynamics Are Independent of BMI-Based Adiposity and BIA-Derived Body Composition and Pubertal Stage in Adolescents with Obesity
Anelise Sonza·Alessandro Sartorio·Graziano Grugni·Diana Caroli·Laura Abbruzzese·Adele Bondesan·Aline Faquin
Background: Sex-related differences in insulin sensitivity during adolescence remain incompletely understood, particularly in the context of obesity. Whether these differences reflect variations in basal insulin resistance or dynamic insulin responses remains unclear. Objective: To investigate sex differences in glucose and insulin responses during the oral glucose tolerance test (OGTT) and to explore mechanisms underlying potential dissociation between glycemic and insulinemic profiles. Methods