mRNA COVID-19 vaccination induces minimal IgA in saliva in the absence of prior clinical or subclinical infection
Tonia L. Conner·Edward Mitre·Hannah Haines-Hull·Allison Segard·Emily S. Darcey·Priscilla Kobi·Bolatito Balogun·Cara Olsen·Dominic Esposito·Milissa U. Jones·Timothy H. Burgess·Robert J. O'Connell·Christopher C. Broder·David Saunders·Simon Pollett·Eric D. Laing·Emilie Goguet
In this prospective cohort study, we analyzed saliva IgA and IgG antibody levels over the first two years of the pandemic after COVID-19 mRNA vaccination and infection. Generally healthy adult healthcare workers with no evidence of prior SARS-CoV-2 infection were enrolled into the Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study between August of 2020 and March of 2021. Utilizing multiplex microsphere-based immunoassays, we measured saliva anti-SARS-CoV-2 spike IgG, IgA, and secr