Loss of SALL1 Promotes Hepatocellular Carcinoma Growth and Is Associated with Poor Clinical Outcome
Y Saito·Frank J. Gonzalez·Atsumi Tamura·Shioko Kimura·Xiaoting Yu·Yutong Cui·Vorthon Sawaswong·Kristopher W. Krausz·Dong Wang·Aijuan Qu·Yusuke Inoue·Shogo Takahashi·Carlos Ichiro Kasano-Camones
Background/Objectives: Hepatocellular carcinoma (HCC) remains a major malignancy with high incidence and mortality, in part due to its diverse etiology and intratumoral heterogeneity, which contributes to drug resistance and frequent recurrence. SALL1 (Spalt-Like Transcription Factor 1), a zinc-finger transcription factor, was reported to function as a tumor suppressor in several cancers, including breast cancer and glioma, and accumulating evidence support its involvement in tumor biology. In t