Time-of-day difference in iron supplementation in iron-deficient pregnant model mice

During pregnancy, iron supplementation is commonly recommended once daily, partly because hepatic hepcidin secretion following iron intake suppresses subsequent iron absorption. However, the optimal timing of iron administration during maternal iron deficiency remains unknown. We established a pregnant mouse model of iron deficiency and compared the effects of iron (FeSO4, 1 mg/kg) supplementation at the beginning (ZT12) and end (ZT0) of the daily active phase of pregnant mice on maternal, place