Mas receptor activation regulates the functional phenotype of myocardial macrophages through the Akt/Nrf2 signaling pathway to alleviate sepsis-induced cardiomyopathy

Sepsis-induced cardiomyopathy (SIC) has high mortality due to uncontrolled cardiac inflammation and macrophage-mediated mitochondrial damage. The Ang-(1–7)/Mas receptor (MasR) axis exhibits anti-inflammatory effects, but its role in modulating macrophage phenotypes in SIC remains unclear. This study aimed to determine if MasR activation confers cardioprotective effects in SIC via the macrophage polarization-regulating Akt/Nrf2 pathway. Blood samples from healthy controls and patients with SIC we