Patterns of Failure in Synchronous Metastatic Non-Small Cell Lung Cancer Without Driver Alterations According to Metastatic Burden

Background: Patterns of failure (POFs) after first-line immune checkpoint inhibitor (ICI)-based therapy in patients with synchronous metastatic non-small cell lung cancer (NSCLC) without oncogenic driver alterations may guide the selection of candidates for local consolidative therapy (LCT). Methods: We retrospectively evaluated patients diagnosed with synchronous metastatic NSCLC between January 2017 and December 2023. Patients with oncogenic driver alterations, those who did not receive ICIs a