Chiral organosilicon compounds featuring a silicon-stereogenic center have attracted renewed interest in recent years. However, the enantioselective synthesis of such molecules containing both carbon and silicon stereocenters from prochiral precursors remains a significant challenge. Herein, we report a desymmetrization strategy that enables the simultaneous construction of two adjacent stereocenters at silicon and carbon. This transformation is achieved through the enantioselective copper-catal