By desuccinylating PCK2 at Lys489, SIRT5 prevents the metabolic reprogramming and subsequent activation of CFBs, protecting against cardiac fibrosis.
SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts
M M Wu·Yangxin Chen·Weibin Zhou·Zenghui Zhang·Qingyuan Gao·Yangwei Cai·Haifeng Zhang·Zhengyu Cao·Chuanrui Zeng·Yi Zhang·Zhiteng Chen·Qiong Qiu·Jing Tan