Bridging Two Worlds: Structural and Pharmacological Aspects of Natural Triterpenoid Dimers: Pristimerin-Pristimerin-Type Dimers

This review summarizes current knowledge on naturally occurring pristimerin-pristimerin triterpenoid dimers, a rare and structurally diverse class of secondary metabolites reported mainly from Celastraceae species. Known dimers are compiled with emphasis on botanical sources and key architectural features, including the variety of interunit linkages, regio- and stereochemical diversity, and distinct isomeric forms (including atropisomerism). Major advances in structure elucidation and structural