Upfront Chemotherapy Versus Immediate Surgery for Operable Pancreatic Cancer: An Umbrella Review of Meta-Analyses
Michele Ghidini·Fausto Petrelli·Lorenzo Dottorini·Andrea Celotti·Annamaria De Giorgi·Gianpaolo Balzano·Francesca Senzani·Gianluca Tomasello·Giuseppe Ietto
Background: Neoadjuvant therapy (NAT) is increasingly investigated in operable pancreatic ductal adenocarcinoma (PDAC), yet its role in strictly resectable disease remains controversial. Randomized trials have been conducted both in borderline resectable and resectable PDAC and have demonstrated survival advantages, while evidence in strictly resectable tumors remains poor. We conducted an umbrella review of systematic reviews and meta-analyses (SRMAs) to comprehensively evaluate the highest lev