DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation
Hongjiao Wang·Zuliang Jie·Songlin He·Songwen Ren·Haiwen Li·刘汪楠·Chunyun Zhou·Pan Zhu·Keren Chen·Weijia Cao·Qin Yan·Dan Du·Nengming Xiao·Hongling Huang·Chun‐Jung Ko·Yiming Zheng·Bo Wang·Qiang Zou·Jianhong Shi·Xun Li·He Jiang
Type 1 conventional dendritic cells (cDC1s) play an integral role in mediating immune responses and maintaining homeostasis, yet the molecular mechanisms underlying their functions remain poorly understood. In this study, we identified dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) as a key kinase that responded to TLR and growth factor stimulation and acted as an essential regulator of cDC1 function. Genetic ablation of Dyrk1a specifically in cDC1s impaired antitumor imm