Radiotherapy (RT) represents a potent approach to activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. However, this immune activation is typically transient and insufficient for long-term tumor control. To overcome this limitation, we developed SCYS-P@MnCO, an X-ray-responsive nanoplatform that integrates radioluminescent scintillating nanoparticles (SCNPs) with photosensitive manganese carbonyl complexes (MnCOs). This design enables the precise, spatiotem