Antifungal mechanism against Candida albicans and antitumor activity of phenazines produced by Pseudomonas sp. strain DH

Candida albicans, a commensal yeast, causes severe infections especially in immunocompromised patients, and microbial secondary metabolites offer sustainable sources for novel antifungal development. This study investigated the antifungal activity against C. albicans CMCC98001 and antitumor potential of phenazines from Pseudomonas sp. strain DH. At 20 µg/mL, 1-hydroxyphenazine (2) and phenazine-1-carboxamide (3) inhibited Aurora-A kinase (a key mitotic regulator). Conversely, they showed no inhi