Exosomes Generated by Normal Peritoneal Cells Driven to Senescence by Carboplatin and Paclitaxel Awaken Dormant Ovarian Cancer Cells and Support Their Growth Reinitiation In Vitro
Szymon Rutecki·Justyna Mikuła-Pietrasik·A. Leśniewska-Bocianowska·Julia Matuszewska·Eryk Naumowicz·Sebastian Szubert·Krzysztof Książek·Adrianna Krawiec
Background: Recurrence poses a major challenge in epithelial ovarian cancer (EOC), often occurring despite optimal first-line therapy. Dormant cancer cells are believed to play a key role, yet the mechanisms driving their reactivation remain unclear. This study examined whether exosomes released by normal peritoneal mesothelial cells (PMCs) and fibroblasts (PFBs) undergoing iatrogenic senescence after carboplatin and paclitaxel exposure contribute to EOC recurrence. Methods and Results: Senescen