Rapid Tubular Accumulation of Renal-Clearable Gold Nanoparticles Enhances Computed Tomography Contrast Imaging of the Kidneys
Yuming Lin·Bujie Du·Mengyi Zheng·Yexi Peng·Yuming Qi·Xunzhi Wu·Mingze Xu·Junyang Zhong·Xingya Jiang·Yuanqing Song
Renal-clearable gold nanoparticles (RC-AuNPs) show promise for kidney computed tomography (CT) imaging by providing structural and functional information. To aid their clinical translation, understanding how their physicochemical properties affect renal CT enhancement is essential. By a head-to-head comparison of glutathione-coated and PEGylated RC-AuNPs (GS-AuNPs and PEG-AuNPs, respectively), we found that while PEG-AuNPs were renally cleared, their slower tubular entry at the early phase led t