Hybrid MXene/Hydrogel Integration with Modulated Bioactivities for Synergistic Diabetic Wound Therapy

Effective management of diabetic wounds requires the simultaneous modulation of bacterial infection, oxidative stress, and angiogenesis. Here, we present a dynamic, self-healing hydrogel platform that integrates Ti₃C₂ MXene nanosheets and epidermal growth factor (EGF) within a glutathione-modified chitosan/alginate network. This injectable system uses dynamic Schiff-base cross-linking to provide superior tissue adhesion and conformability. Under near-infrared (NIR) irradiat