Effect Modification Analyses in Individual Participant Data Meta-Analyses
Ya Gao·Gordon Guyatt·M H Liu·Yunli Zhao·Aminreza Asadollahifar·Kelu Yang·Selina Shi·Mojdeh Daneshmand·Jianguo Xu·Liang Yao·Fengwen Yang·Fuzhong Xue·Jinhui Tian·Junhua Zhang·Zhifan Li
In this systematic review of IPDMAs, protocols and reports often failed to prespecify anticipated effect modification directions, distinguish within-trial from between-trial analyses, and appropriately handle continuous variables. Concordance between protocols and reports was poor, with frequent omission of planned and addition of unplanned effect modification analyses.