Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesis
Kristie Tanavura Bariboloka·Alessandro Annibaldi·Deniz Pinar Savcigil·S. Spoeck·Rebecca E. Poss·Luca D Schreurs·Jens Löber·Nazli Serin·Justinas Valiulis·Kalvin Nugraha·Giulia Gangarossa·Anna Lutz·Moritz Reese·S. Klein·Julius C. Enßle·Reinhard Büttner·Hamid Kashkar·Martin Peifer·Björn Chapuy·Gero Knittel·Verena Labi·Andreas Villunger·Phuong‐Hien Nguyen·Sebastian Scheich·Thomas Oellerich·Henning Walczak·Ruth Flümann·Ron D. Jachimowicz·Michael J Hallek·H Christian Reinhardt·Santiago Serrano-Saenz
Diffuse large B cell lymphoma (DLBCL) is a highly heterogenous malignant disease that remains a major clinical challenge as relapsed and refractory disease is difficult to treat. Apoptosis evasion is a major feature of DLBCL. However, while the suppression of intrinsic apoptosis has long been recognized as a lymphoma-promoting event, the role of extrinsic apoptosis has remained poorly defined. Here, we demonstrated at the genetic level that expression of cFLIP, the most crucial, non-redundant in