Therapeutic Strategies in Glioblastoma and Acute Kidney Injury: Androgen Receptor-Directed Therapy for High-Grade Glioma and Nanoparticle-Based Therapeutic Strategies for Cisplatin-Induced Nephrotoxicity

This dissertation presents two complementary investigations: (1) androgen receptor (AR)-directed therapy in glioblastoma (GBM) and (2) therapeutic and nanoparticle-based strategies for cisplatin-induced acute kidney injury (AKI). The first study identifies AR as a therapeutically actionable target in GBM. Multi-platform analyses revealed elevated AR expression across transcriptional subtypes that correlated with AR protein abundance. Pharmacologic evaluation demonstrated that enzalutamide exhibi