Phytocannabinoid-induced priming and differentiation of mesenchymal stem cells: Therapeutic potential

Mesenchymal stem cells (MSCs) are multipotent progenitor cells extensively studied for their immunomodulatory and regenerative potential. Despite their therapeutic promise, MSC efficacy can be limited by poor survival, reduced homing, and variable immunoregulatory activity in inflammatory microenvironments. To overcome these challenges, priming strategies have been developed to precondition MSCs, enhancing their functional performance. Among these, phytocannabinoids, bioactive compounds derived