Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice

BACKGROUND Anti-aging for the preservation and recovery of physical and brain functions may be a major topic of regenerative medicine in the super-aging society. Stem cells and their secretory active molecules can play a central role of regenerative medicine. AIM To investigate whether extracellular vesicles (EVs) from amniotic membrane stem cells (AMSCs) enhance physical activity, including stamina, and cognitive function in a mouse model of facilitated brain-aging, and to elucidate underlying