The aging epigenome: integrative analyses reveal intersection with Alzheimer’s disease
Wei Zhang·for the Alzheimer’s Disease Neuroimaging Initiative·Juan I. Young·Lissette Gomez·Michael A. Schmidt·Brian W. Kunkle·Xi Chen·Eden R. Martin·Lily Wang·David Lukacsovich
Abstract Aging is the strongest risk factor for Alzheimer’s disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. We performed a meta-analysis of blood DNAm samples from 475 dementia-free subjects aged over 65 years across two independent cohorts, the Framingham Heart Study (FHS) at Exam 9 and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We adjusted for sex and immune cell-type proportions and correcte