Abstract 159: Itaconate promotes memory CD8+ T cell development by epigenetic modification and glucose flux redirection in viral infection and cancer.

Abstract Background: Coordinated metabolic alterations and epigenetic remodeling are known to critically influence T cell fate decisions and functional states. However, the specific extrinsic metabolic signals that guide CD8+ T cell memory differentiation remain to be fully elucidated. Methods: Naïve CD45.1+ OT-I CD8+ T cells were adoptively transferred into Listeria monocytogenes-infected CD45.2 mice to track in vivo differentiation trajectories. Tumor-infiltrating CD8+ T cells were analyzed by