Abstract Septins are a conserved family of GTP-binding cytoskeletal proteins which form oligomeric filamentous structures that play important roles in a wide variety of dynamic cellular processes, including cytokinesis, membrane remodeling and cell migration. Expression of Septins is dysregulated in different tumors, with some isoforms being either upregulated or downregulated, and prior evidence has highlighted a role for several Septins in controlling malignant phenotypes. In particular, Septi