Plasma cell neoplasia is uncommon in cats, and multicentric nodal-predominant involvement has not been well characterized. This report describes a multicentric round cell neoplasia with plasmacytic differentiation in a 14-year-old Domestic Shorthair cat, emphasizing multimodal imaging features and treatment response. Contrast-enhanced computed tomography and magnetic resonance imaging were performed for staging and longitudinal assessment. Cytomorphology supported plasmacytic differentiation, an