Pathogenetic Insight in the Molecularly Defined Subtype of Peripheral T-cell Lymphoma, Not Otherwise Specified

Peripheral T-cell lymphoma (PTCL) includes a varied group of post-thymic T-cell neoplasms; 40% are designated as PTCL-not otherwise specified (PTCL-NOS) due to being unclassifiable within other PTCL entities. Because of this, cases that fall into this category are heterogenous and a specific pathogenic mechanism and treatment regimen is difficult to elucidate. We identified two novel molecular subgroups. PTCL-GATA3 and PTCL-TBX21, within PTCL-NOS cases, designated with distinct T-helper transcri