Early BAL microRNA Signatures Delineate Biological Trajectories Towards CLAD After Lung Transplantation
Gabriella Gaudioso·Valentina Vaira·Riccardo Orlandi·M. De Filippo·Andrea Terrasi·Alessandra Maria Storaci·Nadia Mansour·B. Digiuni·Daniele Marchelli·Luca Vittorio Carlo Valenti·Giorgia De Turris·Frederik von Herz·Giulia Garulli·Mario Nosotti·Letizia Corinna Morlacchi·Francesco Blasi·A. Palleschi·Sara Franzi
Chronic lung allograft dysfunction (CLAD) remains the principal limitation to long-term survival after lung transplantation (LT). Early molecular alterations within the graft may precede clinically overt functional decline, but their biological significance remains incompletely defined. In this single-center exploratory pilot study, 16 bilateral lung transplant recipients underwent bronchoalveolar lavage (BAL) sampling at 7 days, 15 days, and 3 months post-transplantation. BAL-derived microRNA (