Iron and peroxide regulation of the PrrF sRNAs and a conserved ferritin family protein in Pseudomonas aeruginosa and Pseudomonas fluorescens

Iron is a crucial micronutrient for Pseudomonas aeruginosa survival and virulence, yet it can also be toxic due to the production of reactive oxygen species. The PrrF small regulatory RNAs (sRNAs) are transcribed in iron-limiting conditions and block the expression of several mRNAs involved in P. aeruginosa's oxidative stress response. Here, we make the surprising discovery that oxidative stress induces expression of the PrrF sRNAs. We also provide evidence that PrrF regulation of