Antimicrobial activity of cationic carbosilane dendrimers against clinical strains of extended-spectrum beta-lactamase producing-Escherichia coli and their biofilms

<h2>Abstract</h2> Antimicrobial resistance (AMR) is a significance public health concern with serious health and socioeconomic consequences. Therefore, multidrug-resistant strains such as extended-spectrum beta-lactamase (ESBL) producing-Enterobacterales are becoming increasingly common and there are few antibiotic options to treat them. Consequently, it is urgent to find new therapeutic compounds, and cationic dendrimers, such as carbosilane (CBS) derivatives, with peripheral ammonium groups ar