Arteriviruses are diverse +ssRNA viruses (Nidovirales Order; Arteriviridae Family) that infect a variety of mammals. Arterivirus infections can manifest in a variety of ways, ranging from viral hemorrhagic fever to persistent sub-clinical infection. A perplexing feature of arterivirus biology is the unusual network of small glycoproteins that decorate the virion surface. How these glycoproteins mediate viral entry into target cells remains poorly understood, but it is widely accept