Hot-Melt Processed Glibenclamide Glassy Solutions: A Novel Oral Delivery Platform for Enhanced Bioavailability in Diabetes
Hany S.M. Ali·Waleed A Mohammed-Saeid·Ahmed F. Hanafy·Ahmed Almotairy·Marey Almaghrabi·Hamad Alrbyawi
Background/Objectives: Hot-melt injection molding (HMIM) was evaluated as a solvent-free process for the preparation of glibenclamide (GLB), a poorly soluble BCS Class II drug, glassy solutions with the objective of improving dissolution and bioavailability for diabetes. Methods: GLB was blended at a concentration of 10% w/w with PVP K25, PVP VA64, and Soluplus® (SOL) matrices. The miscibility of the GLB–polymer systems (matrices) was calculated based on the Hansen solubility parameters and vali