Fibrin as a thrombin sink: a factor retaining a thrombus in the stillness phase
Alexandra A Yakusheva·Pierre H. Mangin·K A Jouffroy·Muhammad Usman Ahmed·Andréa Thevenot·Charlotte Elisa Fauth·Lise Charle·Matthew J. Flick·Mikhail A Panteleev·Catherine Bourdon
The process of non-occlusive thrombus formation is well known, but the mechanism keeping the thrombus silent at the end stage remains unclear. The aim of this work was to evaluate the role of fibrin in limiting further growth of a thrombotic remnant. Intravital microscopy showed that attachment of platelets to a fibrin-rich thrombus stopped after partial thrombus disaggregation, indicating that the thrombus activation potential is lost, a stage we named the stillness phase. Histological analyses