TPR domain-containing co-chaperones of HSP70 and HSP90 in plants

Protein homeostasis relies on chaperones such as HSP70 and HSP90, which assist in the folding, activation, and turnover of client proteins. Their activity is modulated by co-chaperones, many of which contain tetratricopeptide repeat (TPR) domains. A subset of these, known as carboxylate clamp TPR (CC-TPR) domains, possess distinctive structural features that mediate interactions with the chaperones' C-terminal EEVD motifs. This review focuses on plant TPR-containing co-chaperones, particularly t